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Atherogenesis and cardiovascular risk In the presence of risk factors, such as high fat diet and diabetes, GPx1 deficiency was found to augment atherosclerosis in the context of apolipoprotein E deficient mice (GPx1 −/− ApoE −/− ) [78, 79]
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peptide synthesis is followed by chemical modification, or peptide synthesis is performed using a chemically modified amino acid, or an appropriate reaction condition is selected for the final deprotection of peptide synthesis, as described in a method conventionally known in the art of peptide synthetic chemistry ("Peputidogosei no Kiso to Jikken (Basic and Experimental Peptide Synthesis)" (Nobuo Izumiya, Tetsuo Kato, Haruhiko Aoyagi, Michinori Waki: Maruzen), "Zoku Iyakuhinno Kaihatsu - Dai 14 Kan - Peputido gosei (Development of Pharmaceuticals, Second series, Vol
